In vitro model of full-thickness cartilage defect healing

Histopathological Effects of Loading on Cartilage Repair in a Rat Full-thickness Articular Cartilage Defect Model

[Purpose] We investigated effects of loading on cartilage repair in rat full-thickness articular cartilage defects and histopathologically analyzed the healing process of the defect. [Subjects] A total of 40 male 9-week-old Wistar rats were used. [Methods] Full-thickness articular cartilage defects were created over the capsule at the loading portion in the medial condyle of the femur. Twenty r...

the healing effect of bioglue in articular cartilage defect of femoral condyle in experimental rabbit model

Comparison of Autogenic Costal Cartilage with Chitosan Scaffold in Canine Humeral Defect Healing

Objective- Current trends emphasize the acceleration of fracture healing on the ground that in doing so, the limitation of mobility and complications associated with recovery period are reduced. The present study aims to compare autogenic costal cartilage with Chitosan scaffold in canine humeral defect healing. Design- Experimental study Animal-15 adult male dogs Procedures-...

In vivo repair of full-thickness cartilage defect with human iPSC-derived mesenchymal progenitor cells in a rabbit model

Cell-based tissue engineering has the potential to restore cartilage defects. Induced pluripotent stem cells (iPSCs) are regarded as an alternative cell source in regenerative medicine. The purpose of the present study was to evaluate the use of mesenchymal stem cells (MSCs) derived from human iPSCs (hiPSCs) for the regeneration of cartilage defects in a rabbit model. Cartilage defects were mad...

Viable Osteochondral Allograft for the Treatment of a Full-Thickness Cartilage Defect of the Patella

Isolated cartilage defects can lead to significant pain and disability, prompting the development of a number of options for restorative treatment. Each method has advantages and limitations, and no single technique has gained widespread use. We present a technique for implantation of a cryopreserved osteochondral allograft (Cartiform) for the treatment of full-thickness cartilage defects. Cart...